Short-term n-3 fatty acid supplementation but not aspirin increases plasma proresolving mediators of inflammation
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Short-term docosapentaenoic acid (22:5 n-3) supplementation increases tissue docosapentaenoic acid, DHA and EPA concentrations in rats.
The metabolic fate of dietary n-3 docosapentaenoic acid (DPA) in mammals is currently unknown. The aim of the present study was to determine the extent of conversion of dietary DPA to DHA and EPA in rats. Four groups of male weanling Sprague-Dawley rats (aged 5 weeks) were given 50 mg of DPA, EPA, DHA or oleic acid, daily for 7 d by gavage. At the end of the treatment period, the tissues were a...
متن کاملShort-Term, High-Dose Fish Oil Supplementation Increases the Production of Omega-3 Fatty Acid–Derived Mediators in Patients With Peripheral Artery Disease (the OMEGA-PAD I Trial)
BACKGROUND Patients with peripheral artery disease (PAD) experience significant morbidity and mortality. The OMEGA-PAD I Trial, a randomized, double-blinded, placebo-controlled trial, addressed the hypothesis that short-duration, high-dose n-3 polyunsaturated fatty acids (n-3 PUFA) oral supplementation improves endothelial function and inflammation in PAD. METHODS AND RESULTS Eighty patients ...
متن کاملFish meal supplementation increases bovine plasma and luteal tissue omega-3 fatty acid composition.
The objective of this experiment was to determine if dietary inclusion of fish meal would increase plasma and luteal tissue concentrations of eicosapentaenoic and docosahexaenoic acids. Seventeen nonlactating Angus cows (2 to 8 yr of age) were housed in individual pens and fed a corn silage-based diet for approximately 60 d. Diets were supplemented with fish meal at 5% DMI (a rich source of eic...
متن کاملInfluence of n-3 fatty acid supplementation on the endogenous activities of plasma lipases.
The aim of these studies was to explore the possibility that enhanced triacylglycerol clearance may contribute to the hypotriacylglycerolemic effect of n-3 fatty acids in humans. Healthy subjects (n = 20) and hypertriacylglycerolemic patients (n = 6) were given a placebo (olive oil, OO) or a fish-oil concentrate (FOC; 41% eicosapentaenoic acid and 23% docosahexaenoic acid) in two, independent, ...
متن کاملOmega-3 fatty acid supplementation
Free fatty acids and the risk of sudden death • Elevated circulating free fatty acids have been reported to be a risk factor for sudden death. In the Paris Prospective Study reported by Jouven et al. [ 3 ], 5250 men were observed over a mean follow-up period of 22 years. The concept that omega-3 (n-3) polyunsaturated fatty acids (PUFAs) may have potential health benefits has been supported by e...
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ژورنال
عنوان ژورنال: Journal of Lipid Research
سال: 2014
ISSN: 0022-2275
DOI: 10.1194/jlr.m045583